International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (4): 350-353.doi: 10.3760/ cma.j.issn.1673-5803.2023.04.011

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The role of NETs in the pathogenesis of diabetic retinopathy

Feng Qianhong, Yuan Fei   

  1. Yuan Fei, Email: yuan.fei@zs-hospital.sh.cn
  • Received:2022-10-02 Online:2023-08-22 Published:2023-08-29
  • Contact: Yuan Fei, Email: yuan.fei@zs-hospital.sh.cn
  • Supported by:
    National Nature Science Foundation of China （81873680); Zhongshan Hospital Development Foundation （2020ZSFZ20）

Abstract: Neutrophil extracellular traps(NETs) are network structures composed of nuclear DNA and/or mitochondrial DNA and various proteins released by neutrophils after receiving external stimulation. NETs play an important role in clearing pathogens, inflammation, autoimmunity, etc. Recent years, increasing evidence suggests that NETs are involved in the development of diabetic retinopathy (DR). The hyperglycemic and low-grade inflammatory environment in T2DM can induce NETs in the retina. DR itself also can increase the adhesion of neutrophils in retinal vessels and induce NETs. In addition, some studies have demonstrated that NETs can induce the regression of retinal pathological neovascularization. The study of NETs provides new strategies and directions for the prevention and research of DR. (Int Rev Ophthalmol, 2023, 47: 350-353)

Key words: neutrophil extracellular traps, neutrophils, diabetic retinopathy